Video-game bad guy Ralph and best friend Vanellope von Schweetz leave the comforts of Litwak's arcade in an attempt to save her game, Sugar Rush. Their quest takes them to the vast, uncharted world of the internet where they rely on the citizens of the internet--the Netizens--to help navigate their way.
Ralph (John C. Reilly) is tired of being overshadowed by Fix-It Felix (Jack McBrayer), the "good guy" star of their game who always gets to save the day. But after decades doing the same thing and seeing all the glory go to Felix, Ralph decides he's tired of playing the role of a bad guy. He takes matters into his own massive hands and sets off on a game-hopping journey across the arcade through every generation of video games to prove he's got what it takes to be a hero.
In a city inhabited by anthropomorphic animals who have abandoned traditional predator/prey roles in favor of civilized coexistence, uptight rabbit police officer Judy Hopps (voiced by Ginnifer Goodwin) is forced to work with charismatic fox con artist Nick Wilde (Jason Bateman) to crack a major case involving the mysterious disappearance of some carnivorous citizens. But when a few of the missing critters reappear, having reverted to pre-enlightenment savagery, it exposes existing anti-carnivore prejudice among the city's herbivores that threatens to damage the fabric of their diverse metropolis.